Division of Pathomorphology and Veterinary Forensics

Division of Pathomorphology and Veterinary Forensics

Address
ul. C. K. Norwida 31
50-375 Wrocław

Contact
mgr Faustyna Szmit-Turowska
phone 71 320 5413
email This email address is being protected from spambots. You need JavaScript enabled to view it.

Head of Division
dr Stanisław Dzimira
phone 71 320 5413
email This email address is being protected from spambots. You need JavaScript enabled to view it.

lab


Division's staff
prof. dr hab. Marcin Nowak phone 71 320 5444 email This email address is being protected from spambots. You need JavaScript enabled to view it.
dr Izabela Janus, adiunkt, email This email address is being protected from spambots. You need JavaScript enabled to view it.
dr Rafał Ciaputa, adiunkt phone 71 320 5414 email This email address is being protected from spambots. You need JavaScript enabled to view it.
dr Małgorzata Kandefer-Gola, adiunkt phone 71 320 5414
email This email address is being protected from spambots. You need JavaScript enabled to view it.
Jolanta Dobrowolska, st. technik phone 71 320 5256 email This email address is being protected from spambots. You need JavaScript enabled to view it.
mgr Faustyna Szmit - Turowska, st. technik phone 71 320 5256
email This email address is being protected from spambots. You need JavaScript enabled to view it.
Krzysztof Kwieć, st. technik phone 71 320 5417
dr Alicja Tomaszek, st. technik phone 71 320 5256

PhD students
lek. wet. Paulina Borecka
lek. wet. Magdalena Marzec

Professor emeritus
prof. dr hab. Janusz A. Madej, profesor zwyczajny

RESEARCH:

1. Evaluation of the remodelling of myocardium in dogs with dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD).

Team: Izabela Janus, DVM, Marcin Nowak DVM, PhD, Rafał Ciaputa DVM, PhD, Małgorzata Kandefer-Gola, DVM, PhD, prof. Janusz A. Madej, DVM, PhD (in collaboration with the Department of Internal Diseases: Agnieszka Noszczyk-Nowak, DVM, PhD, prof. Urszula Pasławska, DVM, PhD)

Dilated cardiomyopathy (DCM) and myxomytous mitral valve disease (MMVD) are the most common heart diseases in dogs. The first one occurs most often in large- and giant breed dogs and involves progressing loss of contractility and dilation of left ventricle with a secondary mitral regurgitation and left atrial enlargement. Structural changes can be accompanied by rhythm disturbances (mainly atrial fibrillation). MMVD is a disease in which mitral valve undergoes a progressive degeneration with thickening and stiffness of valve leaflets. Those changes cause mitral regurgitation and left atrial enlargement. Both diseases lead to escalation of heart insufficiency and often do animal’s death.
Both differences (breed predisposition, age of disease onset, various pathomechanism) and similarities (heart chamber enlargement) can be noted between those diseases.
Our research aims to a comparison of histopathological changes present in the myocardium of dogs with DCM and MMVD.
The majority of histopathological studies on these diseases concern on specimens obtained from left ventricle, therefore we begun our research from a comparison of specimens from ventricles and from atria in dogs with DCM and MMVD. We noted that myocardial changes seen in ventricles are expressed on the same or higher level in cardiac atria (Janus et al. 2015).
In the second stage of the research, we compared the histopathological changes (fibrosis, fatty infiltration, vascular changes, cardiomyocyte degeneration) in left atrial specimens from dogs with DCM and MMVD. We have noted that, although both diseases are accompanied by left atrial enlargement, the changes in heart tissue have various character (Janus et al. 2016).
In the next part of our research, we performed an immunohistochemical evaluation of left atrial specimens from dogs with either DCM or MMVD, using various cell markers (desmin, vimentin, periostin, caspase-3, sarcomeric actin, smooth muscle actin, SERCA proteins, dystrophin). In that examination we also found significant differences between these diseases (Janus et al. 2016; Janus et al – paper not yet published).
Our research shows that despite similarities, changes occurring in heart muscle in DCM and MMVD have various character. The differences noted in our work can contribute to better understanding of mechanism underlying these two diseases, that result in clinical signs (e.g. rhythm disturbances).

2. An immunohistochemical evaluation of neoplastic lesions in bitch mammary glands using novel cell markers.
Team: Borecka Paulina, DVM, Marcin Nowak, DVM PhD

Mammary gland tumours are one of the most common neoplasms in bitches. Despite wide range of publications in that topic, usefulness of various cell markers used in human medicine, has not been yet examined in dogs. In our research we will evaluate the reaction of novel neoplastic markers of tumour stroma and lymphatic and blood vessels.
The research will be conducted on specimens of mammary gland neoplasms that were collected during surgery or after death from bitches of various age and breed. Both benign and malignant tumours will be subject of our study. Also the age of an animal and tumour diameter will be analysed. Control group will consist of normal mammary glands form bitches of various breed and age that underwent euthanasia or sudden death and in the necropsy did not show neoplastic lesions, especially in mammary gland.
Specimens from mammary gland will be fixed in 7% buffered formalin, dehydratated and placed in paraffin blocks. A preliminary histopathological examination will be performed after standard haematoxylin-eosin staining basing on Goldschmidt classification. Next, an immunohistochemical analysis, using various markers (Ki67, HER2, podoplanin, vimentin) will be performed. Both monoclonal and polyclonal antibodies will be used in the study. The immunohistochemical reaction will be evaluated using IRS (immune-reactive score) scale, that take into consideration both the percentage of antibody-positive cells and the intensity of reaction. Photomicrographs will be taken from the examined specimens, and statistical analysis (using Statistica 12 for Windows, StatSoft, Poland) will be performed on the results.
The aim of the study is to try to better understand the essence of cancerogenesis and to try to find new markers that can be used in evaluating the prognosis of the disease.

3. Immunohistochemical diagnostics of gonads in dog and cats with disorders of sex development.
Team: Stanisław Dzimira, DVM, PhD, prof. Janusz Madej, DVM, PhD
Sex differentiation disorders (disorders of sex development - DSD) are associated with its unusual differentiation at the chromosomal, gonadal or somatic level. The current division into three main groups DSD in humans, i.e., DSD sex chromosomes, XY DSD and DSD XX was adopted also for dogs and cats.
The aim of the research is immunohistochemical analysis of the gonads of healthy dogs and cats, and animals affected by the disorders of sex development, using antibody markers cytokeratin, desmin, vimentyn, smooth muscle actin, non-specific enolase, inhibin ?, MCM3. The material for the study are the gonads of ten dogs, phenotypic females surgically removed and sent for histopathological examination. And the testes of four cats with disorders of sex development. The control group are the ovaries and testes of ten healthy dogs and testes from five healthy cats obtained after routine surgery gonadectomy. Material fixed in formalin, embedded in paraffin and cut to 4 microns thick sections, stained by routine hematoxylin and eosin. Immunohistochemistry was performed using mono- or polyclonal antibodies from DAKO, ie. Vimentin, desmin, smooth muscle actin, S100, NSE, inhibin alfa and MCM3 proteins.

RESEARCH PROFECTS:
(Title, financing body, project number, period, project leader)

Analysis of hypoxia in epithelial and mesenchymal tumours utilizing hypoxia inducible factor 1 (HIF-1) and blood vessel density in bitches. Project nr N N308 056739 of the Polish Ministry of Science and Higher Education. Period: 26.10.2010 - 26.10.2012. Leader: prof. Janusz A. Madej, DVM, PhD

PUBLICATIONS
(authors, journal name, year, volume no, page, title)
1. Madej J.A.: Pathology and pathogenesis of very rare groups of cancers. Medycyna Weterynaryjna. 2015; 71 (5): 264-275. [Article in Polish. Patomorologia i patogenea bardzo rzadko występujących grup nowotworów]
2. Madej J.A.: "Holy" animals in religion, culture and medicine. Medycyna Weterynaryjna 2015; 71 (6): 399-400. [Article in Polish. "Święte" zwierzęta w religii, kulturze i medycynie]
3. Madej J.A., Madej J.P.: Antitumor defense mechanisms: The causes of failures Medycyna Weterynaryjna. 2015; 71 (9): 534-542. [Article in Polish. Mechanizmy obrony przeciwnowotworowej - przyczyny niepowodzeń]
4. Gajos K. , Kozdrowski R., Nowak M. , Siemieniuch M.J. : Altered secretion of selected arachidonic acid metabolites during subclinical endometritis relative to estrous cycle stage and grade of fibrosis in mares. Theriogenology. 2015, 84, 457–466.
5. Śliwińska-Mossoń M., Milnerowicz S., Nabzdyk S., Kokot I., Nowak M., Milnerowicz H.: The Effect of Smoking on Endothelin-1 in Patients With Chronic Pancreatitis Applied. Immunohistochemistry & Molecular Morphology. 2015, Volume 23 - Issue 4 , 288–296.
6. Felcenloben I., Piasecki T., Miller J., Rossowska J., Bańcyr E., Atamaniuk W., Nowak M., Świerkot J., Ratajczak K., Chełmońska-Soyta A.: Adoptively transferred Tregs accumulate in a site-specific manner and ameliorate signs of less advanced collagen-induced arthritis progress in rats. Immunotherapy. 2015, 7, 215-228.
7. Kozdrowski R., Sikora M., Buczkowska J., Nowak M., Raś A., Dzięcioł M.: Effects of cycle stage and sampling procedure on interpretation of endometrial cytology in mares. Animal Reproduction Science. 2015, 154,56-62.
8. Marcinkowska-Swojak M., Szczerbal I., Pausch H., Nowacka-Woszuk J., Flisikowski K., Dzimira S., Nizanski W., Payan-Carreira R., Fries R., Kozlowski P., Switonski M: Copy number variation in the region harboring SOX9 gene in dogs with testicular or ovotesticular disorder of sex development (78,XX; SRY-negative). Scientific Reports. 2015, 5, 14696. (IF-5,578).
9. Dzimira S., Nizanski W., Ochota M., Madej J.A.: Histopathological pattern of gonads in cases of sex abnormalities in dogs: an attempt of morphological evaluation involving potential for neoplasia. Pathology Research And Practice. 2015, Volume 211, Issue 10. (IF- 1,397)
10. Szczerbal I, Stachowiak M., Dzimira S., Sliwa K., Switonski M.: The first case of 38,XX (SRY-positive) disorder of sex development in a cat. Molecular Cytogenetics. 2015, 8,22 (IF - 2,662)
11. Dzimira S., Madej J. A., Kapuśniak V.: Immunohistochemical diagnostic of hibernoma in dog.Polish Journal Of Veterinary Sciences. 2015, 18, 233-236 (IF - 0,604).
12. Szczerbal I., Niżański W., S. Dzimira S., Nowacka-Woszuk J., Ochota, M. Świtoński M: X monosomy (37,X) in a virilised female cat. Reproduction in Domestic Animals. 2015, 50, 344-348, (IF - 0,1515)
13. Kandefer-Gola M., Nowak M., Madej J. A., Dzimira S., Ciaputa R., Janus I: Useful immunohistochemical indicators in canine mast cell tumours. Acta Veterinaria Hungarica. 2015, 63, 49-59 (IF - 0,646)
14. Janus I, Nowak M, Madej JA. Pathomorphological changes of the myocardium in canine dilated cardiomyopathy (DCM). Bulletin- Veterinary Institute in Pulawy. 2015; 59, 135-142 (IF 0.357).
15. Ciaputa R, Nowak M, Madej JA, Janus I, Górzyńska E, Kandefer-Gola M. Expression of selected markers in immunohistochemical diagnosis of canine and human testicular tumours. Bulletin- Veterinary Institute in Pulawy. 2015; 59: 99-106 (IF 0.357).
16. Kandefer-Gola M, Nowak M, Dzimira S, Janus I, Ciaputa R, Madej JA. COX-2 and mPGES-1 expression in canine mast cell tumour. Medycyna Weterynaryjna 2015; 71: 345-348 (IF 0.218).
17. Ciaputa R, Poradowski D, Janus I, Nowak M, Obmińska-Mrukowicz B, Madej JA, Kandefer-Gola M. Analysis of the expression of N-cadherin and survivin in an established D-17 cell line and in canine cells of spontaneous osteosarcoma. Medycyna Weterynaryjna 2015; 71, 349-353 (IF 0.218).
18. Kandefer-Gola M, Madej JA, Dzimira S, Nowak M, Janus I, Ciaputa R. Comparative analysis of markers of cell proliferation in canine mast cell tumour according to current classifications.Polish Journal Of Veterinary Sciences. 2015; 18: 241-247 (IF 0.604)
19. Woźniak-Biel A, Janeczek M, Janus I, Nowak M. Surgical resection of peripheral odontogenic fibromas in African pygmy hedgehog (Atelerix albiventris): a case study.BMC Veterinary Research. 2015; 11:145 (IF 1.78).
20. Borecka P, Janus I, Ciaputa R, Kandefer-Gola M, Brzozowska M, Hildebrand W, Nowak M. Kidney lymphoma in a young cat. A case report. Weterynaria w Praktyce 2015; 7-8: 66-71. [Article in Polish. Chłoniak nerki u młodego kota. Opis przypadku]
21. Kandefer-Gola M, Madej JA, Dzimira S, Janus I, Nowak M, Ciaputa R. Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours. Bulletin- Veterinary Institute in Pulawy. 2015; 59: 247-253 (IF 0.357).
22. Bakowska M., Kandefer-Gola M.: Mesothelioma in a dog - a case report. Magazyn Weterynaryjny 2015; 24 (217): 12-15. [Article in Polish. Międzybłoniak u psa – opis przypadku]
23. Glińska-Suchocka K., Jankowski M., Borusewicz P., Kubiak K., Spużak J., Dzimira S., Kiełbowicz Z. Peritoneal loose body in cat - case report. Pakistan Veterinary Journal. 2015, 35(4): 534-536.(IF -0,822)
24. Kandefer-Gola M., Lazarczyk M. , Kowalczyk P. , Nowak M., Ciaputa R., Drohobycka-Wawryka A.: Mycobacteriosis of the red-lored amazon parrot: a case report. Veterinarni Medicina, 2016, 61, (3): 233–236.(IF -0,56)
25. Kandefer-Gola M., Nowak M., Ciaputa R., Madej J.A.: Usefulness of immunohistochemical indicators for diagnosis and prognosis of poorly differentiated tumours.Journal of Veterinary Research , 2016, 60, 323-330. (IF- 0,468)
26. Prządka P., Kiełbowicz Z., Osiński B., Dzimira S., Madej J.A, Nowacki W., Kubiak K., Reichert P., Cegielski M: Reconstruction of cranial cruciate ligament in rabbits using polyester implants saturated with PRP, antlerogenic stem cells MIC-1 and their homogenate. Connective Tissue Research, 2016, 1-15 (IF -1,411)
27. Sozanski T., Kucharska A. Z., Rapak A., Szumny D., Trocha M Merwid-Ląd A., Dzimira S., Piasecki T., Piórecki N., Magdalan J., Szeląg A.: Iridoid - loganic acid versus anthocyanins from the cornelian cherry; common and different effects on diet-induced atherosclerosis, PPARs expression, and inflammation. Atherosclerosis 2016, 254, 151-160 (IF – 3,942)
28. Pawlak A., Zioło E., Kutkowska J. Blazejczyk A., Wietrzyk J., Krupa A., Hildebrand W., Dzięgiel P., Dzimira S., Obminska-Mrukowicz B., Strzadala L. Rapak A: A novel canine B-cell leukemia cell line. Establishment, characterization and sensivity to chemotherapeutics. Veterinary and Comparative Oncology, 2016 (IF- 2,452)
29. Szczerbal I., Nowacka-Woszuk J., Dzimira S., Atamaniuk W., Ochota M., Nizanski W., Switonski M.: A rare case of testicular disorder of sex development in a dog (78,XX; SRY-negative) with male external genitalia and analysis of copy number variation in the region upstream of SOX9 gene. Sexual Development, 2016, 10, 74-78. (IF-2,164).
30. Kranc W., Chachuła A., Wojtanowicz-Markiewicz K., Zaorska K., Ociepa E., Piotrowski A., Bukowska D., Ciesiółka S., Borys S., Piotrowska H., Skowrońska A., Nowak M., Antosik P., Brüssow KP, Kempisty B., Bruska M., Nowicki M., Zabel M.: Association between GGA1 gene polymorphisms and occurrence of mammary mixed tumors and aging in domestic bitches. Medycyna Weterynaryjna, 2016, 72, 34-40. (IF- 0,195 )
31. Kempisty B., Zaorska K., Bukowska D., Ciesiółka S., Wojtanowicz-Markiewicz K., Nowak M., Antosik P., Gehrke M., Brüssow KP., Bruska M., Nowicki M., Zabel M.: TP53 gene polymorphisms with mammary gland tumors and aging in bitches. Medycyna Weterynaryjna , 2016, 72, 41-45. (IF- 0,195 )
32. Kempisty B., Zaorska K., Bukowska D., Nowak M., Wojtanowicz-Markiewicz K., Porowski S., Ociepa E., Antosik P., Brüssow KP., Bruska M., Nowicki M., Zabel M.: Analysis of mitogen-activated protein kinase (MAP2K2) gene polymorphisms in relation to the occurrence of adenocarcinoma during aging in dogs. Medycyna Weterynaryjna, 2016, 72, 46-52. (IF- 0,195 )
33. Buczkowska J., Kozdrowski R., Nowak M., Sikora M.: Relationship between uterine biopsy score, endometrial infection and inflammation. Tierarzliche Praksis , 3,158-163, 2016 (IF- 0,305)
34. Siemieniuch M.J., Szóstek A.Z., Gajos K., Kozdrowski R., Nowak M., Okuda K.: Type of inflammation differentially Affects Expression of interleukin 1ß and 6, Tumor necrosis factor-? and toll-like receptors in subclinical endometritis in mares. Plos One, 2016, 11, 5 (IF- 3,057 )
35. Blazejczyk A., Switalska M., Chlopicki S., Marcinek A., Gebicki J., Nowak M., Nasulewicz-Goldeman A., Wietrzyk J.: 1-methylnicotinamide and its structural analog 1,4-dimethylpyridine for the prevention of cancer metastasis. Journal of Experimental and Clinical Cancer Research, 2016, 35, 110 (IF- 4,357 )
36. Bobrek K., Nowak M., Borkowska J., Bobusia K., Gaweł A.: An outbreak of erysipelas in commercial geese. Pakistan Veterinary Journal, 2016, 36, 372-374 (IF- 0,822 )
37. Miernikiewicz P., Kłopot A., Soluch R., Szkuta P., Kęska W., Hodyra-Stefaniak K., Konopka A., Nowak M., Lecion D., Kaźmierczak Z., Majewska J., Harhala M., Górski A., Dąbrowska K.: T4 Phage Tail Adhesin Gp12 Counteracts LPS-Induced Inflammation In Vivo. Frontiers in Microbiology, 2016, 7, 1112 (IF- 4,165 )
38. Nowak M., Madej J.A.: Pula B., Dziegiel P., Ciaputa R.: Expression of matrix metalloproteinase 2 (MMP-2), E-cadherin and Ki-67 in metastatic and nan-metastatic canine mammary carcinomas. Irish Veterinary Journal , 2016, 69,9 (IF- 0,824 )
39. Sikora M., Król J., Nowak M., Stefaniak T., Aubertsson G., Kozdrowski R.: The usefulness of uterine lavage and acute phase protein levels as diagnostic tool for subclinical andometritis in Icelandic mares. Acta Veterinaria Scandinavica, 2016, 58, 50 (IF- 1,230 )
40. Kycko A., Jasik A., Bocian Ł., Otrocka-Domagała I., Mikiewicz M., Śmiech A., Łopuszyński W., Dolka I., Nowak M., Madej JA.: Epidemiological and histopathological analysis of 40 apocrine sweat gland carcinomas in dogs: a retrocpective study. Journal of Veterinary Research , 2016, 60, 331-337 (IF- 0,468 )
41. Madej P. , Madej J.A. , Franik G., Nowak M. Madej-Czech A. , Ciaputa R. , Pluta D. , Pawlicki K. , Gębka P.: The expression of Proangiogenetic Regulator of G-Protein Signaling 5 ( RGS5 Protein ) in Selected Malignant Female Genit Neoplasms. International Journal of Gynecological and Obstetrical Research ,2016, 4, 1-7.
42. Noszczyk-Nowak A., Piasecki T., Cepiel A., Nowak M., Janus I., Pasławska U.: Atrioventricular valvular anomalies and their role in the etiopathogenesis of cardiorespiratory syndrome in farmed common foxes (Vulpes vulpes). Veterinary Quarterly, 2016, 36,1,16-21 (IF- 1,047)
43. Janus I., Noszczyk-Nowak A., Nowak M., Ciaputa R., Kandefer-Gola M., Pasławska U.: A comparison of the histopathologic pattern of the left atrium in canine dilated cardiomyopathy and chronic mitral valve disease. BMC Veterinary Research, 2016, 12:3 (IF- 1,643 )
44. Janus I., Nowak M., Noszczyk-Nowak A., Ciaputa R., Kandefer-Gola M., Pasławska U., Sapierzyński R., Łopuszyński W., Otrocka-Domagała I.: Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014. Acta Veterinaria Hungarica , 2016 , 64,90-102 (IF- 0,871 )
45. Poradowski D., Ciaputa R., Obmińska-Mrukowicz B., Nowak M., Górzyńska E., Janus I.: Comparison of cell markers expression in canine and human spontaneous osteosarcomas and established osteosarcoma cell lines. Pakistan Veterinary Journal 2016,36,25-30 (IF- 0,822 )
46. Ciaputa R., Bandoch P., Lewandowska K., Madej JA., Kandefer-Gola M., Janus I., Nowak M.: Immunohistochemical analysis of metastasising hepatocellular carcinomas in dogs. Veterinarii Medicina , 2016, 61,546-552 (IF- 0,560 )
47. Janus I., Kandefer-Gola M., Ciaputa R., Noszczyk-Nowak A., Pasławska U., Tursi M., Nowak M.: The immunohistochemical evaluation of selected markers in the left atrium of dog with and-stage dilated cardiomyopathy and myxomatous mitral valve disease - a preliminary study. Irish Veterinary Journal ,2016, 69, 18 (IF- 0,824 )
48. Janus I, Skalec A., Kirstein K., Chrószcz A., Janeczek M., Przyborowska-Zhalniarovich P., Mieszkowska M., Adamiak Z. : Ultrasonography and low-field magnetic resonance imaging of the common calcanean tendon in a rabbit model for tendinopathy research: a descriptive study of normal anatomy. Polish Journal of Veterinary Sciences, 2016, 19, 525-534 (IF- 0,719 )
49. Skalec A., Janeczek M. , Janus I. , Chrószcz A. , Henklewski R.: Rabbit common calcanean tendon as an animal model: ultrasonographic anatomy and morphometry. Folia Morphologica 2016;75(1):93-100 (IF- 0,469 )
50. Janus I, Pasławski R., Mazur G., Noszczyk-Nowak A., Cepiel A., Pasławska U.: Atrioventricular valve dysplasia in a dog. Magazyn Weterynaryjny, 2016, 5, 12-17, 2016. [Article in Polish. Dysplazja zastawek przedsionkowo-komorowych u psa.]
51. Janus I., Janeczek M., Najsarek A, Janeczek W. : Surgical extraction of impacted incisor in a dog - a case report. Magazyn Weterynaryjny, 2016, 07-08, 42-46. [Article in Polish. Chirurgiczna ekstrakcja zatrzymanego zęba siecznego u psa - opis przypadku]
52. Dzimira S., Bartnik A., Olszewska A., Wrzosek M., Nicpoń J.,: Fibrosarcoma in a dog - magnetic resonance imaging and treatment - a case report. Magazyn Weterynaryjny,2016, 9, 12-17. [Article in Polish, Włókniakomięsak u psa - obrazowanie rezonansem magnetycznym i leczenie - opis przypadku.]
53. Stefeniak T., Houszka M., Nowaczyk R., Rouibah K., Jawor P.: Zygomycosis of the abdomasum in neonatal calves during treatment of diarrhea caused by Escherichia coli: a case report. Medycyna Weterynaryjna , 2016, 72 (4) 263-267.

PhD theses:
(title, year, author, director of the thesis)

Janusz A. Madej, PhD thesis, 1975. Title: The impact of alloxanic and glucose diabetes on Trichinella spiralis larvae in murine skeletal muscles. Director of the thesis: prof. Czesław Kaszubkiewicz, PhD
Janusz A. Madej, post-doctorate thesis,1982. Title: The impact of exogenous factors on the pathomechanism of lymphatic leukaemia in mouse.

Marek Houszka, PhD thesis, 1974. Title: Morphological and histochemical changes in rabbits poisoned with chwastox (MCPA). Director of the thesis: prof. Czesław Kaszubkiewicz, PhD
Marek Houszka, post-doctorate thesis,1996. Title: The role of mucopolysaccharides in the mechanisms of degeneration and regeneration of alimentary tract mucous membrane due to various pathogenic factors.

Marcin Nowak, PhD thesis, 2004. Title: Ultrastructural study of mitochondria within spontaneous and transplantable epithelial tumors of the mammary glands in animals. Director of the thesis: prof. Janusz A. Madej, DVM PhD
Marcin Nowak, post-doctorate thesis, 2010. Title: The examination of selected human mammary gland tumour markers on mammary gland adenocarcinomas in bitches.

Stanisław Dzimira, PhD thesis, 2005. Title: Immunocytochemical and cytomorphometric diagnostics of malignant lymphomas in dogs. Director of the thesis: prof. Janusz A. Madej, DVM PhD

Rafał Ciaputa, PhD thesis, 2015. Title: The expression of selected cell markers of the most common testicular tumours in dogs and men. Director of the thesis: Marcin Nowak, DVM PhD

Małgorzata Kandefer-Gola, PhD thesis, 2015. Title: The expression of selected cell markers in canine skin mast cell tumours. Director of the thesis: prof. Janusz A. Madej, DVM, PhD, Stanisław Dzimira, DVM, PhD

RESEARCH EQUIPMENT
1. Tissue processor Intelsint ETP RVG
2. Cryostat Leica CM 1850
3. Histologic incubator with temperature control type CLN 32 EA11132
4. Laboratory incubator EN 120
5. Incubator CL-65
6. Paraffin blocks embedding machine
7. Microtome CNO CUT
8. Microtome type SLIDE 2003
9. Re-destilator rel-5 / 5y / h.380v
10. Centrifuge MPW-54
11. Water bath MLL547 / 2/20

RESEARCH OFFER
1. Cytopathological examination of biopsy material
2. Histopathological examination of pets, livestock and wild animals.
3. Histopathological examination of poultry
4. Immunohistochemical examination
5. Postmortem examination of dogs, cats, horses
6. Postmortem examination of livestock
7. Postmortem examination of exotic animals
8. In-field necropsy
9. Disposal of corpses

Log in